Search results for: Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering

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Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering

Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering PDF Author: Volker F. Wendisch
Publisher: Springer Science & Business Media
ISBN: 3540485961
Category : Science
Languages : en
Pages : 413

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Book Description
This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.

Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering

Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering PDF Author: Volker F. Wendisch
Publisher: Springer Science & Business Media
ISBN: 3540485961
Category : Science
Languages : en
Pages : 413

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Book Description
This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.

Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants

Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants PDF Author:
Publisher: Elsevier
ISBN: 0128111232
Category : Medical
Languages : en
Pages : 446

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Book Description
Synthetic Biology and Metabolic Engineering in Plants and Microbes, Part B, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the usage of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways. Continues the legacy of this premier serial with quality chapters authored by leaders in the field of enzymology Contains two volumes covering research methods in synthetic biology and metabolic engineering in plants and microbes Includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways

Engineering Microbial Metabolism For Chemical Synthesis: Reviews And Perspectives

Engineering Microbial Metabolism For Chemical Synthesis: Reviews And Perspectives PDF Author: Yan Yajun
Publisher: World Scientific
ISBN: 1786344319
Category : Science
Languages : en
Pages : 272

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Book Description
Microbial metabolism refers to how microbes obtain energy and nutrients needed to live and reproduce. Its uses in chemical synthesis are multiple, and, when engineered, can provide reliable and reproducible reactions for application in industrial or biogeochemical processes. This book provides expert reviews and perspectives on how to engineer microbial metabolism for chemical synthesis. Major metabolic pathways or networks in microbial systems, including glycolysis, citric acid and photosynthesis, are briefly summarized. Following this, the metabolic engineering efforts of extending these pathways and networks for the biosynthesis of various chemicals are reviewed with the emphasis on the biochemical reactions and engineering strategies. The potential of these pathways for further metabolic engineering are also discussed. From graduate to professional level, cellular metabolism and metabolic engineering applications are introduced to the readers gradually and systematically, making it perfect for students, researchers and practitioners of chemistry, biochemistry and metabolic engineering. Contents: Glycolysis and Its Metabolic Engineering Applications (Jian Wang and Yajun Yan)Citric Acid Cycle and Its Metabolic Engineering Applications (Jia Wang and Xiaolin Shen)Amino Acid Biosynthesis and Its Metabolic Engineering Applications (Yi-Xin Huo)Fatty Acid Biosynthesis and Its Metabolic Engineering Applications (Yi Liu and Tiangang Liu)Photosynthesis and Its Metabolic Engineering Applications (Jason T Ku and Ethan I Lan)Pentose Phosphate Pathway and Its Metabolic Engineering Applications (Ying Wang and Chun Li)Mevalonate/2-Methylerythritol 4-Phosphate Pathways and Their Metabolic Engineering Applications (Xinxiao Sun and Qipeng Yuan)Xylose Metabolism and Its Metabolic Engineering Applications (Maria K McClintock and Kechun Zhang)Engineering Metabolism for the Synthesis of Polyhydroxyalkanoate Biopolymers (Guo-Qiang Chen and Xiao-Ran Jiang) Readership: Graduate students, researchers and practitioners of chemistry, biochemistry and metabolic engineering. Keywords: Microbial Metabolism;Chemical Synthesis;Biosynthesis;Biochemical Reactions;Photosynthesis;Metabolic Engineering;Cellular Metabolism;GlycolysisReview:0

Metabolic Engineering

Metabolic Engineering PDF Author: Sang Yup Lee
Publisher: John Wiley & Sons
ISBN: 352782345X
Category : Science
Languages : en
Pages : 976

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Book Description
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Engineering of Microbial Biosynthetic Pathways

Engineering of Microbial Biosynthetic Pathways PDF Author: Vijai Singh
Publisher: Springer Nature
ISBN: 9811526044
Category : Medical
Languages : en
Pages : 318

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Book Description
This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.

Corynebacterium glutamicum

Corynebacterium glutamicum PDF Author: Masayuki Inui
Publisher: Springer Nature
ISBN: 3030392678
Category : Science
Languages : en
Pages : 378

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Book Description
This updated second edition covers the molecular biology, genome engineering tools and comprehensive analysis techniques for Corynebacterium glutamicum. Aside from modern omics-based approaches, the authors also focus on cell physiology, including cell division, central carbon metabolic pathways, and the respiratory chain. Readers will learn how primary mechanisms like energy metabolism can be applied in processes like biorefinery. Newly added topics include cell envelope structures and aromatic compound metabolism in C. glutamicum. These chapters will be particularly useful for those interested in the microbial production of commodity chemicals, fuels, and proteins. Corynebacteriacea are already some of the most important industrial microorganisms. Understanding the cell physiology of C. glutamicum will help manufacturers to increase their product range and productivity through efficient metabolic engineering.

Systems Metabolic Engineering of Corynebacterium glutamicum towards improved Lysine Production

Systems Metabolic Engineering of Corynebacterium glutamicum towards improved Lysine Production PDF Author: Judith Becker
Publisher: Cuvillier Verlag
ISBN: 3736934262
Category : Science
Languages : en
Pages : 180

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Book Description
L-lysine is an essential amino acid which is mainly applied as supplement in animal feed. With a world market of around 1,000,000 t/a it is one of the most important fermentation products. The gram positive soil bacterium Corynebacterium glutamicum thereby serves as major production organism. The aim of the present work was rational strain engineering of lysine production by C. glutamicum using a systems-oriented approach. Detailed studies on this organism exposed lysine biosynthesis, NADPH metabolism, TCA cycle and precursor supply as key pathways. The central role for strain characterization can here be assigned to 13C metabolic flux analysis, which was also applied in this work to obtain a detailed insight into the cellular physiology. Based on an existing model, the network for flux determination was extended in the present study to increase the number of estimable flux parameters. With regard to strain optimization, targeted modulation of enzyme activities within the cell is crucial to increase or reduce carbon conversion of the selected pathways. The common toolbox such as over expression by promoter exchange or gene deletion was complemented with the method of start codon exchange allowing permanent modulation of enzyme activity. As host-strains for target evaluation, genetically defined, wild type based lysine producers were used which all express a feedback-deregulated variant of aspartate kinase. The most beneficial modifications identified in this work comprised over expression of diaminopimelate dehydrogenase, down-regulation of TCA cycle by attenuation of isocitrate dehydrogenase and engineering of the NADPH metabolism. By subsequent implementation of beneficial targets in a single strain, a rationally designed lysine hyper-producer was created. This exhibited remarkable production properties such as a lysine-HCl titre of 120 g L-1 and a carbon conversion yield of up to 55 %.

Amino Acid Fermentation

Amino Acid Fermentation PDF Author: Atsushi Yokota
Publisher: Springer
ISBN: 4431565205
Category : Science
Languages : en
Pages : 310

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Book Description
This book presents the latest findings on amino acid fermentation and reviews the 50-year history of their development. The book is divided into four parts, the first of which presents a review of amino acid fermentation, past and present. The second part highlights selected examples of amino acid fermentation in more detail, while the third focuses on recent advanced technologies. The last part introduces readers to several topics for future research directions in amino acid production systems. A new field, “amino acid fermentation”, was created by the progress of academic research and industrial development. In 1908, the Japanese researcher Kikunae Ikeda discovered glutamate as an Umami substance. Then a new seasoning, MSG (monosodium glutamate), was commercialized. Although glutamate was extracted from the hydro-lysate of wheat or soybean in the early days, a new production method was subsequently invented – “fermentation” – in which glutamate is produced from sugars such as glucose by a certain bacterium called Corynebacterium. The topic of this volume is particularly connected in a significant way with biochemical, biotechnological, and microbial fields. Both professionals in industry and an academic audience will understand the importance of this volume.

Corynebacterium glutamicum

Corynebacterium glutamicum PDF Author: Nami Tatsumi
Publisher: Springer Science & Business Media
ISBN: 3642298575
Category : Science
Languages : en
Pages : 416

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Book Description
Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.

The Metabolic Pathway Engineering Handbook, Two Volume Set

The Metabolic Pathway Engineering Handbook, Two Volume Set PDF Author: Christina Smolke
Publisher: CRC Press
ISBN: 1420005626
Category : Medical
Languages : en
Pages : 1259

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Book Description
Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab